In multi-center clinical trials, the primary endpoint and/or important secondary endpoints are frequently confirmed by an independent group of clinical experts to make sure that the event meets the specific definitions of the study protocol. This process, Events Adjudication, requires coordination of information flow from the clinical sites who have identified the potential event to the Clinical Events Committee (CEC) and management of the review process. Over the last 18 years, Axio's staff have coordinated events adjudication for several large neurological and cardiovascular trials both NIH and industry sponsored. Our services include:

• Recruitment of physicians for committee membership;
• Drafting the CEC Charter;
• Establishment and maintenance of a study database for event tracking;
• Working with site personnel to obtain complete documentation;
• Management of the event adjudication process including reports for the sponsor and other groups.